Metastasis to the spleen is an uncommon finding in lung cancer and is typically associated with multivisceral disseminated disease. Isolated splenic metastasis in patients with lung cancer is exceedingly rare, with only 50 cases reported in the literature. We report a case of an asymptomatic, metachronous, isolated splenic metastasis in a 66‐year‐old female patient diagnosed 18 months after resection of lung adenocarcinoma. The patient underwent diagnostic and therapeutic splenectomy and remained tumor‐free for 14 years. To our knowledge, this represents the longest reported survival following an isolated splenic metastasis from lung cancer. This case suggests that in well‐selected patients with isolated splenic involvement, aggressive local therapy such as splenectomy can be curative and may lead to exceptional long‐term survival.
Wittlin et al. (2026) studied this question.