Correlation of RUNX2 Variants With Craniofacial–Dental Phenotypes in Cleidocranial Dysplasia

Puntos clave

• This research aims to explore the relationship between RUNX2 variant types and craniofacial-dental traits in Cleidocranial Dysplasia (CCD).
• Analyzed the influence of different RUNX2 variants on cranial base and maxillary morphology.
• Assessed skeletal Class III severity related to RUNX2 variants.
• Evaluated dental anomalies independent of variant types.
• RUNX2 variant type significantly affects cranial base and maxillary morphology.
• Skeletal Class III severity is associated with specific RUNX2 variants.
• Dental anomalies do not correlate with the type of RUNX2 variant.

Resumen