What is the clinical evidence from this study?

Study design: Observational. Population: Preventive cardiology patients receiving mRNA COVID-19 vaccines (n=566). Intervention: mRNA COVID-19 vaccines (Moderna and Pfizer) vs. Pre-vaccine baseline (own control). Primary outcome: Predicted 5-year Acute Coronary Syndrome (ACS) risk (PULS score).

What question did this study set out to answer?

To highlight the increase in endothelial inflammatory markers and risk of acute coronary syndrome (ACS) associated with mRNA COVID vaccines.

April 20, 2026Circulation8 citationsOpen Access

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Correction to: Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning

Resultado clave

mRNA COVID-19 vaccines numerically increased the predicted 5-year acute coronary syndrome risk score from 11% pre-vaccine to 25% post-vaccine in an observational study of 566 patients.

Puntos clave

To highlight the increase in endothelial inflammatory markers and risk of acute coronary syndrome (ACS) associated with mRNA COVID vaccines.
Correction to previously published data on mRNA COVID vaccines' effects.
Reevaluation of findings related to endothelial markers and ACS risk using the PULS cardiac test.
Documented significant increase in endothelial inflammatory markers post-vaccination.
Observed higher ACS risk as measured by PULS test results.

Diseño del estudio

Tipo

Observational (n=566)

Multicéntrico

PICO

Población

Preventive cardiology patients receiving mRNA COVID-19 vaccines (n=566)

Intervención / comparador

mRNA COVID-19 vaccines (Moderna and Pfizer) vs Pre-vaccine baseline (own control) (2 doses)

Resultado principal

Predicted 5-year Acute Coronary Syndrome (ACS) risk (PULS score)

Resultado numérico

Tasa de eventos absoluta: 25% vs 11%

Limitaciones

No statistical comparison was done
No control group of unvaccinated patients or patients treated with other vaccines
Based on data which has not been validated in this population
Single clinic patient population

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Cite This Study

A Tue, study conducted a observational in Preventive cardiology patients receiving mRNA COVID-19 vaccines (n=566). mRNA COVID-19 vaccines (Moderna and Pfizer) vs. Pre-vaccine baseline (own control) was evaluated on Predicted 5-year Acute Coronary Syndrome (ACS) risk (PULS score). mRNA COVID-19 vaccines numerically increased the predicted 5-year acute coronary syndrome risk score from 11% pre-vaccine to 25% post-vaccine in an observational study of 566 patients.

synapsesocial.com/papers/69e598f885ab6d890cfadeb5 https://doi.org/https://doi.org/10.1161/cir.0000000000001053