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April 20, 2026PLoS Biology0 citationsOpen Access

Circadian clock gates diurnal glucose utilization

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YCYao D. CaiJCJoanna C. Chiu

Key Points

  • The study aims to investigate how the circadian clock influences glucose metabolic pathways in Drosophila.
  • Utilized metabolic tracing techniques
  • Analyzed diurnal activities of glucose metabolism
  • Compared wild-type Drosophila with clock and sleep mutants
  • Identified time-of-day-dependent glucose metabolic activities
  • Found disruptions in metabolic pathways in clock and sleep mutants
  • Demonstrated a link between circadian rhythm and glucose utilization

Abstract

The circadian clock and cellular metabolism are tightly coupled to maintain homeostasis. A new study in PLOS Biology leverages metabolic tracing to reveal time-of-day-dependent activities of glucose metabolic pathways in Drosophila that are disrupted in clock and sleep mutants.

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Cite This Study

Cai et al. (2026) studied this question.

synapsesocial.com/papers/69e5c22d03c29399140289eahttps://doi.org/10.1371/journal.pbio.3003743
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Also Consider

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  1. 1Glucose is dynamically regulated by time of day in humans and Drosophila2026 · 1 citations
  2. 2Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in Drosophila2025
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  4. 4Circadian desynchrony and glucose metabolism2024 · 79 citations
  5. 5Overlapping Central Clock Network Circuitry Regulates Circadian Feeding and Activity Rhythms in Drosophila2024 · 2 citations