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April 20, 2026Cancer Cell InternationalOpen Access

TMEM70 drives breast cancer progression via mitochondrial oxidative phosphorylation and microenvironment remodeling

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Authors

BLBoyang LiZHZehao HongRLRuonan Lin

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Overview

This analysis uncovers TMEM70's role in breast cancer progression, highlighting its impact on mitochondrial function and the tumor microenvironment.

Key Points

  • This research aims to define the biological role of TMEM70 in breast cancer and its impact on tumor progression and microenvironment.
  • Integrated bulk transcriptomic, proteomic, spatial transcriptomic, and single-cell RNA-sequencing data.
  • Conducted gain- and loss-of-function assays to assess effects on proliferation, migration, and apoptosis.
  • Performed pharmacogenomic analysis and conducted Connectivity Map screening.
  • Utilized molecular docking to identify candidate therapeutic compounds.
  • TMEM70 was consistently upregulated in breast cancer and associated with poor prognosis across multiple datasets.
  • High TMEM70 expression correlated with an immune-active but constrained microenvironment.
  • TMEM70 enhanced cancer cell proliferation and migration while inhibiting apoptosis.
  • Identified compounds like entinostat and clofibrate associated with high TMEM70 expression.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69e5c2d003c2939914028ca1https://doi.org/10.1186/s12935-026-04303-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TMEM205 promotes M2-like macrophage polarization and advances the progression of triple-negative breast cancer2026
  2. 2TMEM132A is associated with metabolic reprogramming, macrophage-oriented immune remodeling, and breast cancer progression2026 · 6 citations
  3. 3TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH92024 · 24 citations
  4. 4Decoding the Expressions, Immune Relevance, and Prognostic Values of Ferroptosis Gene TMEM189: A Pan-Cancer Analysis2024
  5. 5Elevated TMEM45B expression promotes liver cancer progression and is associated with MET signaling activation2026