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April 20, 2026Open Access

Acupuncture inhibits astrocytic hyperactivation via the p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1 signaling pathway in cerebral ischemia-reperfusion injury

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Authors

ZZZifeng ZhuangCWChoying WOHCH Chen

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Overview

Observational study demonstrates acupuncture reduces astrocyte activation in cerebral ischemia-reperfusion injury, suggesting a therapeutic pathway.

Key Points

  • To investigate how acupuncture affects astrocyte activation through the p38 MAPK/MSK1 signaling pathway after cerebral ischemia-reperfusion injury.
  • Utilized transcriptome and single-cell sequencing to analyze gene expression
  • Conducted experiments on rats subjected to middle cerebral artery occlusion (MCAO)
  • Applied acupuncture as an intervention
  • Assessed astrocyte activation levels post-treatment
  • Acupuncture significantly reduced astrocyte activation in MCAO-induced rats
  • p38 MAPK/MSK1 signaling pathway was inhibited following acupuncture treatment
  • Gene expression profiles indicated reduced inflammatory markers in treated rats

Cite This Study

Zhuang et al. (2026) studied this question.

synapsesocial.com/papers/69e5c2d003c2939914028cabhttps://doi.org/10.19852/j.cnki.jtcm.2026.02.005
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