HIV infection in adults on antiretroviral therapy was associated with a higher prevalence of Type-A arterial waveforms compared to HIV-negative controls (80% vs 57%, p=0.037).
Cross-Sectional (n=111)
No
Does HIV infection on ART alter arterial waveform types compared to HIV-negative controls in Zambian adults?
HIV status in adults on ART is associated with a shift toward Type-A arterial waveforms, indicating altered arterial function and increased vascular risk.
Absolute Event Rate: 80% vs 57%
p-value: p=0.037
People living with HIV (PLWH) experience a greater risk of cardiovascular disease due to HIV-related vascular injury. Pulse waveform analysis can characterize arterial vascular dysfunction and this study compared arterial waveforms in PLWH on antiretroviral therapy (ART) with HIV-negative controls. In this cross-sectional study, participants were recruited from the University Teaching Hospitals, Lusaka (September 2018-June 2019). 55 PLWH on ART ≥2 years and 56 HIV-negative controls were recruited. Anthropometry, body composition, haemodynamics, and pressure waveforms were recorded using the Complior Analyze unit with their corresponding pulse wave velocities. Waveforms were classified by augmentation-index/pulse-pressure ratio as Types A (≥0.12), B (0-0.12), or C (2(2) = 48.17, p < 0.001). HIV status is associated with a shift toward Type-A waveform, reflecting altered arterial function. Pulse waveform analysis may serve as a useful non-invasive tool for vascular risk profiling in PLWH.
Chikopela et al. (2026) conducted a cross-sectional in HIV (n=111). HIV infection on antiretroviral therapy vs. HIV-negative controls was evaluated on Type-A arterial waveform (augmentation-index/pulse-pressure ratio ≥0.12) (p=0.037). HIV infection in adults on antiretroviral therapy was associated with a higher prevalence of Type-A arterial waveforms compared to HIV-negative controls (80% vs 57%, p=0.037).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: