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April 21, 2026European Heart JournalOpen Access

Combining genetic variants and cardiovascular risk factors facilitates the identification of high-risk individuals for targeted prevention of dementia.

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Design

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Key result

Combining genetic variants and cardiovascular risk factors facilitates the identification of high-risk individuals for targeted prevention of dementia.

Authors

IRIda Juul RasmussenRFRuth Frikke‐Schmidt

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Overview

Genetic-CV profiling may enable targeted dementia prevention; leaves open shared pathogenesis and requires trials before clinical adoption.

Key Points

  • This research aims to explore the relationship between cardiovascular risk factors and genetics in preventing dementia.
  • Utilized genome-wide association studies to identify disease-associated genetic loci.
  • Assessed the impact of cardiovascular risk factors on dementia risk.
  • Proposed a targeted intervention strategy for high-risk individuals.
  • A 10% reduction in cardiovascular risk factors could theoretically prevent over nine million dementia cases worldwide by 2050.
  • Highlights the importance of exploring shared causal risk factors between cardiovascular disease and dementia.
  • Suggests that targeted interventions can significantly benefit those at high risk based on genetic profiles.

PICO

P
Population
Dementia
I
Intervention / Comparator
Targeted prevention using genetics and cardiovascular risk factors

Cardiovascular risk factors and genetic information may help identify individuals at high risk for dementia who could benefit from targeted prevention strategies.

Limitations

  • Survivor selection bias in observational and genetic cross-sectional studies
  • Confounding in observational studies
  • Pleiotropic effects of genetic instruments in Mendelian randomization studies
  • Selected samples in two-sample MR designs may not represent the general population

Cite This Study

Rasmussen et al. (2023) conducted a review in Dementia. Targeted prevention using genetics and cardiovascular risk factors was evaluated. Combining genetic variants and cardiovascular risk factors facilitates the identification of high-risk individuals for targeted prevention of dementia.

synapsesocial.com/papers/69e6eca792d553e56bf21f6chttps://doi.org/10.1093/eurheartj/ehad293
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