Parenting Concerns and Emotional Distress in Cancer Patients With Minor Children: A Meta‐Analysis of Key Moderators

ABSTRACT Background Parenting concerns, stemming from cancer's projected impact on children, are a common and significant source of emotional distress for parents. A quantitative synthesis of existing data is critically absent, and the role of modulating factors (e.g., male sex, single parenthood, and the number of children) remains unclear. Aims This meta‐analysis aims to quantify the association between parenting concerns and emotional distress in cancer patients, examining male sex, single parenthood, and number of children as key moderators. Methods This systematic review and meta‐analysis followed PRISMA guidelines. Searches (PubMed, Embase, PsycINFO, Airiti Library; inception‐November 2025) identified observational studies of adult cancer patients with minor children. Data on parenting concerns, anxiety, and depression were extracted and appraised using a modified JBI Checklist. Correlations were synthesized. Meta‐regression addressed the quantitative void, examining male sex, single parenthood, and number of children as key moderators. Publication bias and sensitivity were assessed. Results We included 12 studies ( N = 3895). Our meta‐analysis found significant positive associations ( r = 0.50, p < 0.001) between parenting concerns and both anxiety and depression. Meta‐regression, controlling for time since diagnosis, identified male sex, single parenthood, and fewer children as significant moderators for anxiety ( p < 0.001), with similar trends for depression. Linking Evidence to Action This meta‐analysis highlights parenting concerns linked to distress in cancer patients, with fathers, single parents, and those with fewer children particularly vulnerable. Routine assessment and tailored, family‐centered psychosocial interventions are urgently needed. PROSPERO Registration This systematic review was registered with the International Prospective Register of Systematic Reviews and Meta‐analysis (PROSPERO; Registration No. CRD42024592899).