Wave-Native Pharmacokinetics: Programming Mechanical Substrates for Sustained and Triggered Drug Release

This work introduces a new class of programmable drug‑delivery substrates that operate through mechanical logic rather than passive chemical dissolution. By applying the Frequency‑Encoded Elastic Network (FEEN) framework to zwitterionic block co‑polymers, the paper demonstrates how nonlinear Duffing oscillator mechanics can be embedded directly into a biomaterial. The result is a dual‑regime delivery matrix: a monostable domain (B > 0) that provides clean, tunable, high‑efficiency sustained release, and a bistable domain (B < 0) that functions as a mechanically locked reservoir requiring a biological “AND” gate to deploy its payload. Localized pH shifts attenuate the energy barrier, while stress‑responsive enzymes supply the kinetic impulse needed to trigger a rapid structural snap and acute drug release. The Intenxan benchmark illustrates how a single substrate can deliver a 3–4 hour cognitive‑focus window while reserving an anxiolytic compound for genuine physiological distress. This document establishes the architecture as open prior art, merging nonlinear dynamics, phononic logic, and polymer science into a foundation for event‑driven, programmable pharmacokinetics.