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April 22, 2026Advanced Composites and Hybrid MaterialsOpen Access

Thermo-responsive astaxanthin-polymeric nanocarriers targeting STAT3-RIPK1 mediated PANoptosome formation for neuroprotection in retinal injury

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Authors

RRRong RongJLJiamiao LiuGLGanghao Liang

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Overview

Demonstrates neuroprotection in retinal injury using thermosensitive nanocarriers, suggesting a novel therapeutic strategy.

Key Points

  • To investigate the role of STAT3 in retinal ischemia-reperfusion injury and develop a targeted therapeutic approach.
  • Developed thermosensitive astaxanthin-polymeric nanocarrier with STAT3 inhibitor Stattic.
  • Evaluated protective effects of the nanocarrier on retinal ganglion cells and optic nerve in a mouse model of retinal injury.
  • Conducted assessments of visual function and cellular damage post-treatment.
  • ASX-NP significantly reduced retinal ganglion cell loss in RIR model mice.
  • Restored visual function was observed following treatment with ASX-NP.
  • The protective effects were linked to inhibition of the STAT3-RIPK1-PANoptosis pathway.

Cite This Study

Rong et al. (2026) studied this question.

synapsesocial.com/papers/69e864866e0dea528dde9586https://doi.org/10.1007/s42114-026-01800-z
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