Manganese-catalysed HIE of Arenes and Heteroarenes

Key Points

• This research examines manganese-catalyzed hydrogen isotope exchange as a sustainable alternative to precious metal catalysts for the incorporation of deuterium into molecules.
• Utilized manganese as a catalyst for hydrogen isotope exchange in various arenes and heteroarenes.
• Evaluated the efficiency and sustainability of the manganese-catalyzed process compared to traditional precious metal methods.
• Manganese demonstrated comparable efficacy to precious metal catalysts in facilitating hydrogen isotope exchange.
• Significantly reduced environmental impact and physiological toxicity were observed with the manganese catalyst.