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April 22, 20261 citations

Perioperative FLOT Chemotherapy in Resectable Gastric Adenocarcinoma: A Single-center Retrospective Observational Study.

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HNHemasireesha NattiVGVishesh GumdalDKDeepak Koppaka

Key Points

  • To evaluate the effectiveness and challenges of FLOT chemotherapy in patients with resectable gastric adenocarcinoma.
  • Conducted a retrospective observational study at a single center
  • Analyzed surgical resection rates and treatment adherence
  • Evaluated the safety profile of FLOT chemotherapy
  • FLOT chemotherapy resulted in a lower-than-expected surgical resection rate
  • High attrition rates indicated challenges in treatment adherence
  • Need for improved patient selection strategies was emphasized

Abstract

While FLOT demonstrated an acceptable safety profile, the lower-than-expected surgical resection rate and high attrition highlight the challenges in managing locally advanced gastric cancer in real-world settings. This study emphasizes the need for strategies to improve treatment adherence and optimize patient selection to maximize the benefits of perioperative chemotherapy for gastric cancer.

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Cite This Study

Natti et al. (2026) studied this question.

synapsesocial.com/papers/69e865126e0dea528dde9a1dhttps://doi.org/10.59556/japi.74.1456
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