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April 22, 2026Journal of Materials Chemistry B0 citationsOpen Access

Poly-L-Lysine integration in PVA hydrogels enables stable, bioactive matrices for motor neuron differentiation and neural network formation

SWShuqian WanDEDorna EsrafilzadehLPLaura A. Poole‐Warren

Key Points

  • The aim is to evaluate how Poly-L-Lysine affects motor neuron differentiation within PVA hydrogels.
  • Incorporation of Poly-L-Lysine into PVA hydrogels
  • Assessment of motor neuron differentiation
  • Evaluation of neural network formation
  • Poly-L-Lysine modifications improved cell adhesion and viability
  • Enhanced neuronal differentiation observed in treated hydrogels
  • Formation of functional neural networks was more effective in the integrated hydrogels

Abstract

The regeneration of motor neurons remains a major challenge in neural tissue engineering due to the complex cellular architecture and dynamic microenvironment of neural systems.While three-dimensional (3D) hydrogels offer a...

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Cite This Study

Wan et al. (2026) studied this question.

synapsesocial.com/papers/69e865126e0dea528dde9ab6https://doi.org/10.1039/d5tb02475g
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