Abstract An uncommon histiocytic lesion of the tongue was described in an 11‐year‐7‐month‐old male Shih Tzu dog that presented with multiple nodules on the upper lip and tongue, with further dissemination on the ventral lingual surface observed during sedation. Histopathology revealed poorly demarcated aggregates of large vacuolated histiocyte‐like cells within the lamina propria and occasionally among muscle fibres, accompanied by mild epithelial hyperplasia and focal haemorrhage without mitotic figures or cytological atypia. Special staining (PAS, Alcian blue) was negative. These features are consistent with multiple histiocytic foam cell nodules of the tongue, a rare lesion reported almost exclusively in miniature dachshunds. This case broadens the recognised breed spectrum and highlights the need for thorough histopathological and histochemical evaluation to distinguish this benign condition from xanthomas, inflammatory proliferations and common lingual neoplasms, such as melanomas and squamous cell carcinomas.
Gregorio et al. (Mon,) studied this question.