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April 22, 2026RSC Advances0 citationsOpen Access

Surface-confined FRET nanoplatform printed via pyro-EHD jet for stable and reproducible TNF-α detection

SCStefania CarboneSRSimone RussoAPAnna Palma

Key Points

  • The aim is to develop a stable and reproducible method for detecting TNF-α using a FRET nanoplatform.
  • Utilized pyro-EHD jet printing to create microspots of P52 with fixed donor-acceptor spacing.
  • Developed a surface-confined FRET system to enhance detection sensitivity.
  • Evaluated detection limits of the platform for TNF-α.
  • Achieved a limit of detection at 31 ng mL−1 for TNF-α.
  • Demonstrated high reproducibility in measurements across multiple tests.
  • Showed consistent sensitivity and performance of the nanoplatform.

Abstract

A p-jet/F-ZnO 2D FRET nanoplatform enables surface-confined TNF-α detection by printing P52 microspots with fixed donor–acceptor spacing. The system ensures high reproducibility and sensitivity, achieving a 31 ng mL −1 limit of detection.

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Cite This Study

Carbone et al. (2026) studied this question.

synapsesocial.com/papers/69e866ad6e0dea528ddeafc7https://doi.org/10.1039/d6ra00144k
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