This work introduces Structural Medicine v1.0, a minimal and falsifiable framework that redefines disease as a structural transition rather than a failure of components. Within the framework of Integrated Structural Generation Theory (IGS), biological systems are described through the generative chain: Difference → Fixation → Information → Meaning → Time The central proposal is: “Disease is not a failure of components, but a transition of structure.” In this formulation, disease corresponds to the breakdown of persistent structural fixation under irreversible differentiation, formally expressed as: dF/dt < 0 A minimal dynamic model is given by: F(t) = F₀ exp(-λt) The framework further introduces a structural classification of disease states, distinguishing between fixation loss, connectivity loss, and local overgrowth. To ensure direct falsifiability, structural variables are mapped to measurable clinical observables, including imaging (MRI/CT), network activity (EEG/fMRI), longitudinal markers, and cognitive tests. Crucially, disease progression is interpreted as a measurable drift in these observables over time, linking theoretical structure to empirical data. This work provides a unified structural interpretation of biological, cognitive, and clinical systems, offering a new conceptual foundation for understanding disease.
Koji Okino (2026) studied this question.