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April 22, 2026International Endodontic Journal0 citationsOpen Access

Dentine Regeneration With Calcium Strontium Silicate: In Vitro Odontogenic Differentiation, Antimicrobial Activity, Immunomodulation and In Vivo Pulpotomy in Rat Molars

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MAMohamed Mahmoud AbdallaVRVidhyashree RajasekarHAHeba Ahmed

Key Points

  • The research aims to evaluate the regenerative capacity and antibacterial properties of calcium strontium silicate in dentine regeneration.
  • Conducted in vitro tests for odontogenic differentiation and antimicrobial activity.
  • Performed in vivo pulpotomy on rat molars to assess clinical outcomes.
  • Evaluated biocompatibility and immunomodulatory effects.
  • CSR showed enhanced biocompatibility compared to conventional materials like MTA.
  • Demonstrated superior regenerative potential and odontogenic differentiation.
  • Exhibited significant antibacterial properties, improving clinical effectiveness.

Abstract

CSR demonstrated superior biocompatibility, regenerative potential, and antibacterial properties making it a promising alternative to MTA for VPT, enhancing clinical outcomes.

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Cite This Study

Abdalla et al. (2026) studied this question.

synapsesocial.com/papers/69e866ad6e0dea528ddeb135https://doi.org/10.1111/iej.70165
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