What does this research mean for the field?

The neutrophil-lymphocyte ratio (NLR) is significantly associated with established perioperative risk scores and systemic illness, demonstrating its utility as a biomarker for preoperative risk stratification in major noncardiac surgery. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to assess the Neutrophil-Lymphocyte Ratio (NLR) as a biomarker for perioperative risk in noncardiac surgical patients.

April 22, 2026

Examination and Validation of Neutrophil-Lymphocyte Ratio as a Perioperative Risk Assessment Biomarker in Major Noncardiac Surgical Patients: An Observational Cross-sectional Study.

Key Points

This research aims to assess the Neutrophil-Lymphocyte Ratio (NLR) as a biomarker for perioperative risk in noncardiac surgical patients.
Conducted an observational cross-sectional study

Structured PICO

Does Neutrophil-Lymphocyte Ratio (NLR) correlate with perioperative risk assessment scores in major noncardiac surgical patients?

Population

Major noncardiac surgical patients

Intervention

Neutrophil-Lymphocyte Ratio (NLR) assessment

Outcome

Association with systemic illness and preoperative risk scores (ASA PS Classification System, RCRI, ARISCAT score, and Gupta's postoperative respiratory failure risk)surrogate

NLR may serve as a valuable biomarker in preoperative risk stratification for major noncardiac surgical patients.

Abstract

Significant association has been observed between increased NLR and occurrence of systemic illness. NLR also has a significant association with ASA PS Classification System, RCRI, ARISCAT score, and Gupta's postoperative respiratory failure risk. So, NLR may serve as a valuable biomarker in preoperative risk stratification.

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