Myeloablative Busulfan, Fludarabine and Melphalan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Childhood Myeloid Malignancy

Puntos clave

• To evaluate the safety and efficacy of busulfan, fludarabine, and melphalan conditioning before allogeneic hematopoietic stem cell transplantation for children with high-risk myeloid malignancies.
• Utilized myeloablative conditioning with busulfan, fludarabine, and melphalan
• Administered to heavily pretreated children
• Assessed tolerance and effectiveness before HSCT
• Conditioning was well tolerated by children
• Demonstrated effectiveness as a treatment option
• Supported use in high-risk populations before transplantation