April 23, 2026Journal of drug targeting0 citations
Development of Venlafaxine Hydrochloride Nasal Thermosensitive In-Situ Gel with P407/P188: Enhanced Bioavailability and Antidepressant Effects in Depressive Rats
The research aims to develop a nasal gel formulation of venlafaxine to improve its bioavailability and antidepressant effects.
Created a P407/P188 thermosensitive gel for nasal administration.
Conducted experiments on depressive rats to evaluate bioavailability and efficacy.
Analyzed the sustained release of venlafaxine in the gel formulation.
The nasal gel significantly improved the bioavailability of venlafaxine compared to traditional forms.
Enhanced antidepressant effects were observed in treated rats.
Sustained release characteristics were confirmed, indicating effective brain targeting.
Abstract
This innovative P407/P188-based gel enhances VEN bioavailability and antidepressant efficacy via sustained release and brain targeting, providing critical data for nasal formulation development.