Antimicrobial resistance (AMR) is a rising global health concern that requires the discovery of novel bioactive natural products.Marine-derived Streptomyces geysiriensis represents a promising source of pharmacologically important secondary metabolites.In this study, the production of metabolites and antibacterial activity were significantly enhanced by optimizing physicochemical and nutritional parameters.The crude ethyl acetate extract was obtained through submerged fermentation.Chaetoglobosin A was successfully isolated and purified using chromatographic techniques and structurally characterized by UV-Vis, FT-IR, LC-MS, and NMR analyses.The purified compound exhibited moderate antioxidant and anti-inflammatory activities.Additionally, Chaetoglobosin A demonstrated antibacterial and antibiofilm activity against clinically important pathogens including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Enterococcus faecalis.These findings highlight the metabolic diversity of marine Streptomyces and emphasize their importance as a valuable source of bioactive secondary metabolites with potential pharmacological relevance.
B. et al. (2026) studied this question.