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April 23, 2026BMC PediatricsOpen Access

NINJ1 as a novel biomarker of intestinal injury in necrotizing enterocolitis

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Authors

DMDandan MoKCKaiyue CuiJCJiatong Chen

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Overview

This observational study evaluates NINJ1 for assessing intestinal injury severity in neonates with necrotizing enterocolitis, indicating its potential clinical utility.

Key Points

  • This research aims to investigate NINJ1's role as a biomarker for intestinal injury severity in necrotizing enterocolitis (NEC) in neonates.
  • Conducted a prospective observational study with neonates diagnosed with NEC and controls.
  • Measured serum NINJ1 levels via ELISA and evaluated tissue expression through immunohistochemistry.
  • Performed ROC analysis to assess diagnostic performance for surgical intervention and bowel perforation.
  • Serum NINJ1 levels were significantly elevated in NEC neonates compared to controls (p < 0.001).
  • NINJ1 outperformed other markers like PCT and CRP in predicting surgical intervention (AUC: 0.73).
  • Combining NINJ1 with CRP and PCT improved prediction accuracy for surgery to AUC: 0.79.

Cite This Study

Mo et al. (2026) studied this question.

synapsesocial.com/papers/69e9b77885696592c86eb4dfhttps://doi.org/10.1186/s12887-026-06754-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NINJ1: A Novel Sepsis Severity and Mortality Biomarker2024 · 5 citations
  2. 2A26-14 U-shaped Association Between Plasma Ninj1 Levels and Clinical Outcomes in Patients With Pneumonia-induced Acute Respiratory Failure2026
  3. 3Changes in Serum Levels of NINJ1 and HMGB1 in Children with Kawasaki Disease and Their Clinical Significance2026
  4. 4Predictive biomarkers for post-neonatal necrotizing enterocolitis intestinal stenosis: Role of JMJD3, CRP, and PCT.2025
  5. 5Hematologic Inflammatory Indices Predict Mortality in Surgical Necrotizing Enterocolitis Among Premature Infants2026