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April 23, 2026Current Atherosclerosis Reports0 citationsOpen Access

Cardiovascular Disease and Dyslipidemia in Pediatric Type 1 Diabetes

GKGrace K. KimPBPreneet Cheema BrarNBNidhi Bansal

Key Result

Pediatric type 1 diabetes is associated with premature cardiovascular disease mortality, with dyslipidemia serving as a highly prevalent and undertreated modifiable risk factor.

Key Points

  • This research aims to understand the impact of dyslipidemia on cardiovascular disease risk in pediatric patients with type 1 diabetes.
  • Reviewed existing literature on cardiovascular disease mortality in type 1 diabetes
  • Analyzed the prevalence and management of dyslipidemia as a cardiovascular risk factor
  • Evaluated safety and efficacy of statins in children with type 1 diabetes
  • Dyslipidemia is prevalent and often undertreated in pediatric patients with type 1 diabetes
  • Statins are safe and effective in improving lipid levels and reducing cardiovascular risk
  • Type 1 diabetes is associated with increased risk of premature cardiovascular disease mortality

Structured PICO

P
Population
Pediatric patients with Type 1 Diabetes
I
Intervention
Dyslipidemia management, primarily statin therapy

Dyslipidemia is a highly prevalent and undertreated cardiovascular risk factor in pediatric type 1 diabetes, and optimizing its management, primarily with statins, is crucial to potentially decrease premature cardiovascular disease risk.

Limitations

  • Specific long-term data regarding improvement in mortality and cardiovascular disease outcomes in youth with type 1 diabetes on long-term lipid-lowering therapy is lacking.
  • The pathophysiology of increased atherosclerosis and cardiovascular disease in patients with type 1 diabetes is multifactorial and not fully understood.

Abstract

Despite advances in type 1 diabetes (T1D) management, mortality is still increased, with cardiovascular disease (CVD) as the leading cause. Dyslipidemia is a highly prevalent modifiable CVD risk factor. We reviewed the existing literature on CVD mortality in T1D to highlight CVD risk in pediatric patients with T1D. Pathophysiology of T1D and premature CVD risk is still not fully understood. Dyslipidemia remains a highly prevalent and undertreated CV risk factor in T1D. Statins have been shown to be safe and effective to improve CVD risk in adults with T1D, and in children with familial hypercholesterolemia, in addition to improving lipids levels in children with T1D. T1D is associated with premature CVD mortality, and dyslipidemia is still a highly prevalent and undertreated CVD risk factor. We aim to educate and empower pediatric providers to optimize management of dyslipidemia in pediatric patients with T1D to potentially decrease the CVD risk.

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Cite This Study

Kim et al. (2026) conducted a review in Pediatric Type 1 Diabetes and Dyslipidemia. Pediatric type 1 diabetes is associated with premature cardiovascular disease mortality, with dyslipidemia serving as a highly prevalent and undertreated modifiable risk factor.

synapsesocial.com/papers/69e9b7c585696592c86eb5dahttps://doi.org/10.1007/s11883-026-01409-z
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