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April 23, 2026Lab on a Chip0 citationsOpen Access

Independent parallel production of tunable blood clot analogues in hourglass-profiled circular PDMS fluidic channels

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CHChun-Hsin HsuTCTo-Wen ChenWSWei-Jen Soong

Key Points

  • The aim is to understand the production and characteristics of blood clot analogs to improve therapies for occlusive thrombi.
  • Used hourglass-profiled circular PDMS channels for fluidic studies
  • Created tunable blood clot analogs to analyze properties
  • Investigated the determinants of recanalization success
  • Successfully produced tunable blood clot analogs that mimic real thrombi
  • Identified key factors that influence occlusion and recanalization processes
  • Demonstrated the potential of this method for future thrombus studies

Abstract

Rapid removal of occluding blood clots, whether by intravenous thrombolysis or endovascular thrombectomy, can be life-saving. Yet recanalization is not always successful, and the determinants remain incompletely understood. Thrombi exhibit...

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Cite This Study

Hsu et al. (2026) studied this question.

synapsesocial.com/papers/69e9b85585696592c86eb9f4https://doi.org/10.1039/d6lc00190d
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