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April 23, 2026Journal of Clinical Medicine0 citationsOpen Access

Health Outcomes Associated with Blood Lipid Levels and Korean Medicine Utilization in Elderly Population from the NHIS Database: A Retrospective Cohort Study

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SHS. HongJJJi-cheon JeongDCDong-jun Choi

Key Points

  • This research aims to explore the relationship between Korean Medicine utilization and health outcomes related to blood lipid levels in the elderly.
  • Conducted a retrospective cohort study using NHIS database from health examinations (2009-2010).
  • Participants were divided into Korean Medicine and non-Korean Medicine groups and matched for age, sex, income, and comorbidities using propensity score matching.
  • Analyzed primary outcomes of mortality and disease diagnosis, along with secondary outcomes of medical spending and utilization.
  • Korean Medicine utilization is linked to significantly lower all-cause mortality (HR 0.93; 95% CI 0.87–1.00; p = 0.048).
  • Statin users in the Korean Medicine group had a notable reduction in mortality risk (HR 0.91; 95% CI 0.84–0.99; p = 0.022).
  • Participants using Korean Medicine had a higher incidence of disease diagnosis, suggesting increased healthcare engagement.

Abstract

Background: The elderly are vulnerable to chronic diseases and altered lipid metabolism, leading to poor outcomes, including mortality. We investigated the association between Korean Medicine (KM) utilization, blood lipid levels, and health outcomes using the National Health Insurance Service Sample Cohort (NHIS-NSC) database. Methods: This retrospective cohort study included elderly participants who underwent health examinations (2009–2010). Participants were divided into KM and non-KM groups and matched 1:1 using propensity score matching (PSM) for age, sex, income, and comorbidities. Primary outcomes were mortality and disease diagnosis; secondary outcomes included medical spending and utilization. Results: After PSM, 13,044 subjects were analyzed. KM utilization was associated with a significantly lower risk of all-cause mortality (HR 0.93; 95% CI 0.87–1.00; p = 0.048). However, the hypolipidemia subgroup showed no significant differences in all-cause mortality and medical expenses compared to other lipid status subgroups. While the KM group showed a higher incidence of disease diagnosis (HR 1.09; 95% CI 1.04–1.14; p < 0.001), this may reflect increased healthcare engagement and proactive health-seeking behavior. Subgroup analysis revealed that statin users in the KM group had a significantly reduced mortality risk (HR 0.91; 95% CI 0.84–0.99; p = 0.022). Medical expenses and utilization were higher in the KM group. Being underweight or aged over 85 was associated with higher mortality. Conclusions: KM utilization is associated with reduced all-cause mortality after propensity score matching, particularly among statin users. Although KM users had a higher cumulative incidence of disease diagnosis, this potentially reflects increased diagnostic opportunities from prolonged survival. Hypolipidemia, underweight, and late-elderly status remain significant risk factors associated with frailty. KM may support improved survival in the elderly, warranting further prospective studies.

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Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/69e9b89b85696592c86ebb0chttps://doi.org/10.3390/jcm15083150
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