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April 23, 2026Organic Process Research & Development

Mechanistic Investigation of a Domino N–H and C–H Borylation in the Manufacture of AMG 193

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Authors

CWConner V. WilsonMEMaria Victoria Silva ElipeSMSharon Michalak

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Overview

Investigation reveals improved C–H activation and reduced iridium use in AMG 193 manufacture, suggesting efficient production pathways.

Key Points

  • The research aims to optimize the manufacturing process of AMG 193 by investigating the mechanistic details of borylation reactions.
  • Developed an iridium-catalyzed tandem N–H/C–H borylation procedure
  • Performed kinetic analysis comparing N–H and C–H activation rates
  • Utilized in situ reaction monitoring techniques like ReactIR and NMR
  • Achieved a 10-fold reduction in iridium catalyst usage
  • Identified that N-boryl functionalization inhibits C–H activation
  • Established faster rates for N–H activation compared to C–H activation

Cite This Study

Wilson et al. (2026) studied this question.

synapsesocial.com/papers/69e9b89b85696592c86ebb1bhttps://doi.org/10.1021/acs.oprd.6c00043
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