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April 23, 2026Open Access

Pernicious Anemia Resulting in Intramedullary Hemolysis, Masking Underlying Polycythemia Vera and Mild Alpha-Thalassemia-A Case Report.

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Authors

ARAmanda RohnerASAnnatina Sara Schnegg-KaufmannYBYara Banz

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Overview

Case report reveals pernicious anemia masking polycythemia vera and alpha-thalassemia, indicating diagnostic challenges.

Key Points

  • To highlight how vitamin B12 deficiency can obscure the diagnosis of underlying myeloproliferative neoplasms like polycythemia vera and alpha-thalassemia.
  • Presented case of a 48-year-old woman with fatigue, weight loss, and pancytopenia.
  • Conducted laboratory tests, bone marrow biopsy, and molecular analysis.
  • Provided treatment with vitamin B12 supplementation and monitored for hematologic changes.
  • Severe vitamin B12 deficiency led to intramedullary hemolysis and cytopenias.
  • After treatment, the patient exhibited polycythemia, leukocytosis, and a JAK2 V617F mutation confirmed PV.
  • Alpha-thalassemia was diagnosed alongside these conditions.

Cite This Study

Rohner et al. (2026) studied this question.

synapsesocial.com/papers/69e9b89b85696592c86ebb3bhttps://doi.org/10.48620/97126
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pernicious Anemia Resulting in Intramedullary Hemolysis, Masking Underlying Polycythemia Vera and Mild Alpha‐Thalassemia—A Case Report2026
  2. 2Pernicious Anemia Mimicking Thrombotic Thrombocytopenic Purpura in the Setting of Severe Vitamin B12 Deficiency2026
  3. 3Not All Hemolysis Is Hemolytic: A Case of Pernicious Anemia2026
  4. 4Hemolytic Anemia and Pancytopenia Secondary to Vitamin B12 Deficiency: Evaluation and Clinical Significance2024 · 3 citations
  5. 5Pseudomicroangiopathic Thrombotic Syndrome: Unveiling the Vitamin B12 Deficiency Connection2024