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April 23, 2026Nature MetabolismOpen Access

A conserved hormonal signalling–H2A.Z axis rapidly reorganizes 3D chromatin interactions in adipocyte thermogenesis

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Authors

YZYang ZhangRZRongbin ZhengTTTadataka Tsuji

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Overview

Research demonstrates hormonal signalling reorganizes chromatin to activate thermogenic genes in adipocytes, suggesting a new metabolism control pathway.

Key Points

  • The study aims to understand how β3-adrenergic receptor signalling affects chromatin structure and gene regulation during adipocyte thermogenesis.
  • Used Micro-C to create 3D genome maps of mouse and human brown adipocytes during thermogenesis
  • Analyzed chromatin changes and gene activation in response to β3-AR stimulation
  • Investigated the role of the H2A.Z histone variant and its effects on thermogenic activity and glucose tolerance.
  • β3-AR signalling reorganizes chromatin loops within 4 hours, linking loop formation to thermogenic gene activation
  • H2A.Z deposition increases chromatin accessibility, facilitating the recruitment of MED1 and loop formation
  • Loss of H2A.Z significantly impairs thermogenic activity and glucose tolerance in mice.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69e9b89b85696592c86ebc00https://doi.org/10.1038/s42255-026-01510-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 17690 Acute hormonal signaling-induced 3D genome organization controls transcriptional dynamics during adipocyte thermogenesis2024
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  5. 5Upregulation of Inhibitor of DNA Binding 1 and 3 is Important for Efficient Thermogenic Response in Human Adipocytes2024