Syphilis is known as the great imitator due to its variety of clinical presentations. It is also known to have a widely variable timeline for each of its manifestations, although the causes of each of these differing timelines are not yet well established in the literature. The purpose of this case is to highlight a patient with rapidly progressive syphilis, including cutaneous and ocular manifestations, with a brief discussion of factors contributing to timelines and variability of syphilis presentations.
Santharam et al. (2026) studied this question.