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April 23, 2026RSC Advances0 citationsOpen Access

TAPP-based fluorescent probes for selective cysteine detection: insights into structure–reactivity relationships

EGEren Sahin GocenFDFatma DemirtasHAHande Akar

Key Points

  • The aim is to explore how different chemical structures affect the reactivity of fluorescent probes with cysteine.
  • Designed and synthesized TAPP-based fluorescent probes
  • Functionalized probes with aldehyde, malononitrile, and cyanoacrylate groups
  • Investigated structure-reactivity relationships in cysteine detection.
  • Identified specific structural features that enhance cysteine detection
  • Demonstrated effective fluorescence responses for different probe designs
  • Potential for improved selectivity in detecting cysteine in biological samples.

Abstract

Herein, a series of TAPP-based π-conjugated fluorescent probes functionalized with aldehyde, malononitrile, and cyanoacrylate groups were designed and synthesized to investigate structure–reactivity relationships in cysteine (Cys) sensing.

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Cite This Study

Gocen et al. (2026) studied this question.

synapsesocial.com/papers/69e9baa885696592c86ecae1https://doi.org/10.1039/d6ra02033j
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