The aim is to explore cyclic peptidomimetics as modulators of melanocortin receptor activity.
Synthesis of diverse cyclic peptidomimetics
Characterization of their binding affinity to MCRs
Evaluation of receptor activation in cellular assays
Certain cyclic peptidomimetics show enhanced binding affinity for MCRs
The cyclic structures influence receptor activation dynamics
Potential therapeutic implications for conditions related to MCR dysregulation
Abstract
The melanocortin receptor (MCR) family consists of five G protein-coupled receptors (MC1R-MC5R) that are activated by peptide hormones α, β and γ-MSH and ACTH. These receptors are involved in diverse...