The modulatory role of 6-gingerol-rich portion of ginger on brain oxidative stress, inflammation and neurotransmission in chronic unpredicted mild stress-induced depressed male Wistar rats.
The study aims to evaluate the effects of 6-gingerol on brain health and function in a depression model.
Utilized a model of chronic unpredicted mild stress in male Wistar rats.
Administered a 6-gingerol-rich extract to assess its effects on brain parameters.
Monitored oxidative stress and inflammation in the brain.
6-gingerol significantly reduced oxidative stress markers in the brain.
It demonstrated anti-inflammatory effects, reducing inflammation-related indicators.
Improvement in neurotransmission processes was observed in treated rats.
Abstract
Consequently, the study reveals the role of 6-GIRPOG in ameliorating CUMS-induced depression and brain damage via antioxidative, anti-inflammatory, and neurotransmission modulatory mechanisms.