Background Cervical ectopy is a common physiological condition in women of reproductive age and may be associated with symptoms such as vaginal discharge, postcoital bleeding, dyspareunia, and pelvic pain. While ablative treatments are frequently used in symptomatic cases, interest in non-ablative approaches has increased. This study evaluated clinical and epithelial changes following vaginal hyaluronic acid therapy in women with symptomatic cervical ectopy. Methods This prospective observational study included 121 women diagnosed with symptomatic benign cervical ectopy. All participants received hyaluronic acid vaginal ovules (Cicatridine) once daily for 14 days. Follow-up was performed at 4 weeks, 8 weeks, and 3 months after treatment. Epithelial transformation was assessed by quantifying the extent of columnar epithelium during speculum examination. Temporal changes were analyzed using repeated-measures ANOVA. Results The mean epithelial transformation rate increased progressively from 61.5% ± 19.8 at 4 weeks to 74.6% ± 21.2 at 8 weeks and 82.9% ± 20.4 at 3 months ( p 0.001). Clinical follow-up notes suggested a trend toward symptom relief; however, symptom change was recorded descriptively without a validated scoring instrument. Conclusion Vaginal hyaluronic acid therapy was associated with progressive epithelial transformation in women with symptomatic cervical ectopy, with descriptively observed symptom relief. However, because of the observational design, absence of a control group, and non-standardized symptom assessment, these findings should be interpreted as exploratory. Further randomized controlled trials are required to determine clinical effectiveness.
Yanar et al. (2026) studied this question.