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April 24, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Impact of SpaceOAR on Radiation Therapy Plans for Prostate Cancer

Comparative analysis of radiation therapy plans before and after biodegradable hydrogel (SpaceOAR) injection for reducing rectal toxicity in patients with prostate cancer undergoing carbon ion radiotherapy

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Authors

HKHyun Jin KimHKHojin KimSKSunmi Kim

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Overview

Comparative analysis reveals SpaceOAR reduces rectal toxicity in prostate cancer patients receiving carbon ion radiotherapy, suggesting enhanced safety.

Key Points

  • This research evaluates the effects of SpaceOAR on radiation dose distribution and treatment plan robustness in carbon ion radiotherapy for prostate cancer.
  • Included 25 patients with localized prostate cancer undergoing SpaceOAR insertion.
  • Compared treatment plans using conventional dosimetry and robust evaluation methods including dose-volume histograms and ProKnow scoring.
  • Assessed plan stability against potential patient setup uncertainties.
  • SpaceOAR significantly reduced rectal radiation dose in all patients compared to conventional plans (p < 0.001).
  • Improvements in overall treatment plan quality were noted through enhanced DVH metrics and ProKnow scores (p < 0.001).
  • Robustness evaluations indicated increased safety and reliability for treatment plans using SpaceOAR.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69eb07a4553a5433e34b3311https://doi.org/10.3389/fonc.2026.1805204
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