Higher PPAR-γ levels may be associated with a potentially compensatory or neuroprotective pattern, particularly in adolescents with MDD, whereas the inverse correlations observed in the MDD-PF group may indicate a different or disrupted regulatory pattern in more severe presentations. Overall, PPAR-γ may be linked to executive functioning in adolescent depression, warranting confirmation in larger longitudinal studies.
Karaca et al. (Wed,) studied this question.