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April 24, 2026PLoS ONE1 citationsOpen Access

Impact of Early Systematic Antidepressant Therapy on Affect and Impulsivity in Bipolar Disorder

A cross-sectional study on the impact of early systematic antidepressant therapy on positive/negative affect and impulsivity in euthymic bipolar disorder patients

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Authors

DHDongyu HanPCPeng CuiMWMingjin Wang

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Overview

Cross-sectional study assesses antidepressant effects on affect and impulsivity in bipolar disorder patients, indicating careful prescription is essential.

Key Points

  • The study aims to evaluate the effects of early systematic antidepressant therapy on impulsivity and positive/negative affect in euthymic bipolar disorder patients.
  • Cross-sectional analysis involving 124 Han Chinese bipolar disorder patients
  • Participants divided into two groups: systematic antidepressant treatment (AT) and no treatment (NT)
  • Measured outcomes included Positive and Negative Affect Scale and Barratt Impulsiveness Scale; statistical analyses applied.
  • AT group showed higher levels of negative affect and various impulsivity metrics compared to NT group
  • No significant difference in positive affect or motor impulsivity was observed
  • Negative affect did not mediate the relationship between antidepressant treatment and impulsivity.

Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/69eb09c9553a5433e34b41b4https://doi.org/10.1371/journal.pone.0346872
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