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April 24, 2026BMC CancerOpen Access

Effect of electronic cigarette aerosols on cisplatin resistance in head and neck cancer cells: a collaborative replication study

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Authors

RERosalia EmmaGCGiuseppe CarotaKPKonstantinos Partsinevelos

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Overview

Multicenter study investigates e-cigarette impact on cisplatin resistance in head and neck cancer, suggesting cautious interpretation of findings.

Key Points

  • This study aims to verify if e-cigarette aerosols influence cisplatin resistance in head and neck squamous cell carcinoma (HNSCC) cells.
  • Conducted multicenter in vitro study using standardized protocols.
  • Assessed effects of various nicotine concentrations from e-cig aerosols and cigarette smoke on specific HNSCC cell lines.
  • Evaluated cisplatin sensitivity and gene/protein expressions through various assays.
  • E-cig aerosols did not significantly affect cisplatin sensitivity across all tested HNSCC cell lines.
  • IC50 values and cytotoxicity assays were similar for cells treated with e-cig aerosols and those treated with cisplatin only.
  • Gene and protein expression changes in cisplatin transporters and DNA repair were inconsistent.

Cite This Study

Emma et al. (2026) studied this question.

synapsesocial.com/papers/69eb0a2e553a5433e34b46adhttps://doi.org/10.1186/s12885-026-16029-8
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