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April 24, 2026Neurosurgery0 citations

Long-Term Outcomes After Gamma Knife Radiosurgery for Craniopharyngioma: A Single-Center Retrospective Study

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JRJheremy S ReyesABAlexandros BourasCHConstantinos G. Hadjipanayis

Key Points

  • This study examines the long-term effectiveness of gamma knife radiosurgery for treating craniopharyngioma.
  • Conducted a retrospective analysis at a single center
  • Evaluated radiographic control and symptom management outcomes
  • Assessed the impact of tumor volume on treatment efficacy
  • Gamma knife radiosurgery provided durable radiographic control for patients
  • Higher tumor volume was linked to poorer radiographic outcomes
  • The ≥12.5 Gy dosage in larger tumors needs further validation

Abstract

GKRS achieved durable radiographic control, while symptom-driven interventions were common and should be incorporated into clinically relevant disease control endpoints. Larger volume was associated with worse radiographic control; the ≥12.5 Gy signal in higher-volume tumors warrants validation.

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Cite This Study

Reyes et al. (2026) studied this question.

synapsesocial.com/papers/69eb0a66553a5433e34b47cahttps://doi.org/10.1227/neu.0000000000004081
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