Transcriptional Profiles of Somatostatin and Parvalbumin Interneuron Subtypes in the Human Dorsolateral Prefrontal Cortex: Implications for Schizophrenia

Key Points

• The study aims to identify transcriptional profiles of somatostatin and parvalbumin interneuron subtypes in the human DLPFC and their relevance to schizophrenia.
• Analyzed transcriptional profiles of SST and PVALB interneurons in healthy adults.
• Focused on young and middle-aged adults without psychiatric disorders.
• Discovered distinct subtypes of SST and PVALB interneurons in the DLPFC.
• Proposed that changes in representation or gene expression of these subtypes may be linked to schizophrenia.