PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 24, 2026Investigative Ophthalmology & Visual Science0 citationsOpen Access

Genetic Architecture of Trans-Laminar Cribrosa Pressure Difference and Primary Open-Angle Glaucoma

View Full Paper
IHIn-Shik HongCCChamlee ChoBKBeomsu Kim

Key Points

  • The research focuses on identifying genetic factors associated with trans-laminar cribrosa pressure difference (TLCPD) in the context of primary open-angle glaucoma (POAG).
  • Analyzed genetic variants and associated genes in UKBB participants of European ancestry.
  • Investigated cell types and tissues linked to TLCPD.
  • Examined the relationship between TLCPD and POAG susceptibility.
  • Identified specific genetic variants associated with TLCPD.
  • Demonstrated a link between TLCPD and the risk of developing POAG.
  • Highlighted potential contributions of these variants to disease pathogenesis.

Abstract

This study identified TLCPD-associated variants, genes, cell types, tissues, and diseases in UKBB participants of European ancestry. These findings support the clinical relevance of TLCPD in glaucoma pathogenesis, implicating TLCPD-related genetic variants as contributor to POAG susceptibility.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/69eb0bc7553a5433e34b5573https://doi.org/10.1167/iovs.67.4.51
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC12020 · 12 citations
  2. 2Interplay between Müller cells and microglia aggravates retinal inflammatory response in experimental glaucoma2021 · 131 citations
  3. 3Impact of Systemic Blood Pressure on the Relationship between Intraocular Pressure and Blood Flow in the Optic Nerve Head of Nonhuman Primates2009 · 72 citations
  4. 4The GTEx Consortium atlas of genetic regulatory effects across human tissues2020 · 6,140 citations
  5. 5Response of Blood Flow to Warm and Cold in Normal and Low-Tension Glaucoma Patients1988 · 336 citations