What question did this study set out to answer?

This study aims to evaluate and compare the fluoride release properties of three restorative materials over various time intervals.

April 25, 2026Open Access

An In Vitro Study on the Comparative Assessment of Fluoride Release Capabilities of Three Types of Restorative Materials

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This study aims to evaluate and compare the fluoride release properties of three restorative materials over various time intervals.
In vitro study with thirty disk-shaped specimens (10 per group) prepared according to manufacturer specifications.
Fluoride release was measured at 1, 7, 14, 21, and 28 days using a fluoride ion-selective electrode.
Statistical analysis was performed using Kruskal-Wallis and Bonferroni post hoc tests.
Cention N had the highest fluoride release overall, peaking at 11.1 ppm on day 7.
GC Fuji IX showed a second peak of fluoride release on day 14.
Ionolux exhibited moderate but consistent fluoride release throughout the study period.

Resumen

Aims and background:This in vitro study aimed to compare the fluoride-releasing properties of three different restorative materials-GC type IX (conventional glass ionomer cement), Ionolux (resin-modified glass ionomer cement), and Cention N (alkasite material)-at multiple time intervals.Dental caries remains a prevalent global health issue, particularly among children.Fluoride-releasing restorative materials are widely used in pediatric dentistry due to their ability to inhibit demineralization and promote remineralization.Materials and methods: Thirty disk-shaped specimens (10 per group) were prepared according to the manufacturer's instructions and stored in deionized water.Fluoride ion release was measured using a fluoride ion-selective electrode at 5 intervals: 1, 7, 14, 21, and 28 days.Data were statistically analyzed using Kruskal-Wallis and Bonferroni post hoc tests.Results: All three materials exhibited the highest fluoride release on the 7th day, followed by a decline.Cention N showed the greatest fluoride release overall, peaking significantly on day 7 (11.1 ppm).GC Fuji IX had a second peak on day 14, while Ionolux exhibited moderate but consistent fluoride release throughout the study period. Conclusion:Cention N released the highest amount of fluoride among the materials tested, indicating its strong potential for caries prevention.All materials demonstrated an initial burst release followed by a gradual decline, aligning with effective long-term fluoride delivery.The findings support the continued use of fluoride-releasing materials in minimally invasive pediatric restorative dentistry.Clinical significance: This study highlights that Cention N and Ionolux can offer handling and esthetic benefits.Effective and sustained fluoride release profiles, especially the initial high release followed by a controlled decline, support their use in minimally invasive and preventive dentistry.

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