Increasing microtubule stability drove cardiomyocyte widening, whereas decreasing stability promoted cellular lengthening by disrupting the intercalated disc.
Microtubule dynamics act as a toggle to direct cardiomyocyte growth, coordinating local translation and structural remodeling for bidirectional growth.
The adult heart grows by addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. Here, we found that microtubule dynamics could act as a toggle to direct cardiomyocyte growth. Increasing microtubule stability drove cellular widening, concomitant with redirecting mRNA export and translation along the width of the cell and reinforcement of the intercalated disc. Conversely, decreasing microtubule stability promoted cellular lengthening, disrupting the intercalated disc and biasing translation and incorporation of new sarcomeric protein toward this structure. Notably, disrupting intercalated disc adhesion was sufficient for cardiomyocyte elongation, yet dispensable for cardiomyocyte widening. Thus, the heart coordinates local translation and structural remodeling to orchestrate bidirectional growth.
Scarborough et al. (2026) studied Cardiomyocyte growth. Modulation of microtubule stability was evaluated on Direction of cardiomyocyte growth. Increasing microtubule stability drove cardiomyocyte widening, whereas decreasing stability promoted cellular lengthening by disrupting the intercalated disc.