What question did this study set out to answer?

This research aims to determine the effectiveness of different models in identifying high-risk smoldering multiple myeloma (SMM) patients.

April 25, 2026

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Identifying High-Risk Smoldering Multiple Myeloma for Early Intervention

CMCecilie V. MaengUniversity of Copenhagen SRSæmundur Rögnvaldsson CBChristian BrieghelRoskilde Sygehus

Key Points

This research aims to determine the effectiveness of different models in identifying high-risk smoldering multiple myeloma (SMM) patients.
Cohort study comparing the AQUILA trial criteria with the 2/20/20 model.
Assessment of patient classification rates between models.
Analysis of progression risks associated with each model.
AQUILA trial criteria identified approximately three times more patients as high-risk compared to the 2/20/20 model.
The 2/20/20 model captured a subgroup with significantly lower progression risk.
Findings suggest the 2/20/20 model more accurately identifies truly high-risk SMM patients for potential early intervention.

Abstract

This cohort study found that the AQUILA trial criteria classified approximately 3 times more patients with SMM as having high risk compared with the 2/20/20 model and captured a group with substantially lower progression risk. These results suggest that the 2/20/20 model more accurately identifies a truly high-risk group with SMM, for whom early treatment is more likely to be beneficial.

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Cite This Study

Maeng et al. (Thu,) studied this question.

synapsesocial.com/papers/69ec5ae988ba6daa22dac66f https://doi.org/https://doi.org/10.1001/jamaoncol.2026.0831

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