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April 25, 2026Bioscience Biotechnology and Biochemistry1 citationsOpen Access

Mitochondrial NADP+-isocitrate dehydrogenase Idp1 involves CoQ biosynthesis in parallel with NAD kinase Pos5

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SNShogo NishiharaYMYasuhiro MatsuoMKMakoto Kawamukai

Key Points

  • To investigate the involvement of mitochondrial NADP+-isocitrate dehydrogenase Idp1 and NAD kinase Pos5 in CoQ biosynthesis.
  • Studied Schizosaccharomyces pombe with deletions of idp1 and pos5 to observe effects on coenzyme Q levels.
  • Measured NADP+/NADPH ratios and mitochondrial NADPH pools in mutant strains.
  • Deletion of idp1 decreased coenzyme Q levels; further reduction occurred with additional pos5 deletion.
  • The NADP+/NADPH ratio in the ∆idp1 strain shifted to an oxidized state, indicating altered redox state.

Abstract

Mitochondrial NADPH is synthesized by isocitrate dehydrogenase (Idp1) from NADP+ and NAD kinase (Pos5) from NADH. Coenzyme Q levels in Schizosaccharomyces pombe were decreased by deletion of idp1 and further lowered by deletion of pos5. The NADP+/NADPH ratio of the ∆idp1 strain shifted to an oxidized state. The mitochondrial NADPH pool and its redox state are critical for CoQ biosynthesis.

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Cite This Study

Nishihara et al. (2026) studied this question.

synapsesocial.com/papers/69ec5b0688ba6daa22dac9b1https://doi.org/10.1093/bbb/zbag059
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