Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies (Adv. Funct. Mater. 33/2026)

Key Points

• This research aims to mimic and study the one-way connections between different brain regions to understand how neuropathologies propagate.
• Developed an in vitro brain model using brain organoids to replicate unidirectional long-range connections.
• Examined the propagation of electrical activity and neuroinflammatory responses in response to neurotoxic proteins.
• Demonstrated that electrical activity propagates directionally within the model.
• Observed significant neuroinflammatory responses and neurotoxic protein activity in one direction.

Abstract