Common Coronary Artery Disease Risk Variants in Endothelial Regulatory Elements Modulate Tetraspanin 14 Expression and Notch Signaling

Key Points

• The study aims to determine how CAD-associated genetic variants influence TSPAN14 expression and Notch signaling in endothelial cells.
• Identified CAD-associated variants at the 10q23 locus.
• Examined the effect of these variants on TSPAN14 expression.
• Analyzed downstream Notch signaling pathways in endothelial cells.
• The regulatory element at the 10q23 locus modulates TSPAN14 expression in endothelial cells.
• Changes in TSPAN14 expression significantly impact Notch signaling activity.
• The findings establish a genetic link between CAD risk and endothelial dysfunction.

Abstract