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April 26, 2026The Journal of Experimental Medicine

IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens

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Authors

RTRoser Tachó‐PiñotHBHabib BashourMFMartyna Filipska

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Overview

Randomized trial shows IgD responses to environmental antigens in memory B cells, indicating their role in mucosal immunity.

Key Points

  • This research aims to understand how IgD responses from memory B cells and plasma cells target specific antigens in the nasopharyngeal mucosa.
  • Analyzed human tonsils for IgD-PC and IgD-ME B cell populations.
  • Studied the developmental origins and functional significance of IgD responses in tonsils.
  • Considered transcriptional and phenotypic properties of atypical B cells among IgD-ME B cells.
  • Identified that most IgD-PCs emerge from IgD-ME B cells in various nasopharyngeal regions.
  • Demonstrated that IgD-ME B cells have a mutational pathway influenced by innate and adaptive signals.
  • Showed that secreted IgD responses target respiratory commensal bacteria and environmental antigens.

Cite This Study

Tachó‐Piñot et al. (2026) studied this question.

synapsesocial.com/papers/69edaa9b4a46254e215b30c2https://doi.org/10.1084/jem.20251752
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