Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 26, 2026SHILAP Revista de lepidopterologíaOpen Access

Integrated transcriptomic profiling combined with in vitro validation reveals the involvement of TMEM140 in the link between periodontitis and brain aging

View Full Paper
Ask AI
Bookmark
Share

Authors

HZHaoran ZhaoHWHongtao WangWLWenhua Li

Discussion

Loading...

Member takes

Overview

Randomized trial shows TMEM140's involvement in brain aging linked to periodontitis, indicating potential therapeutic targets.

Key Points

  • This study aims to explore the molecular connections between periodontitis and brain aging, focusing on TMEM140.
  • Integrated transcriptomic analysis from GEO database for PD and AD datasets
  • Machine learning algorithms (RF, SVM, GLM, XGB) to identify key genes
  • In vitro experiments using inflammatory models in human gingival fibroblasts and neuron-like cells.
  • Seven common aging-related genes were identified between PD and AD including TMEM140, which was upregulated in PD and downregulated in AD.
  • TMEM140 knockdown in neuron-like cells led to increased injury, higher ROS production, and elevated inflammatory markers such as IL-1β and TNF-α.
  • These findings suggest that reduced TMEM140 increases neuron-like cells' vulnerability to inflammatory stress.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69edaafc4a46254e215b3373https://doi.org/10.3389/fnagi.2026.1761218
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrative Transcriptomic and Machine Learning Analysis Identifies Key Senescence‐Associated Secretory Phenotype Genes Associated With Immune Dysregulation in Periodontitis2025
  2. 2Assessment of the Association of Periodontitis and Diabetes Mellitus with Alzheimer’s Disease in a Mouse Model2026
  3. 3Porphyromonas gingivalis outer membrane vesicles drive neuroinflammation via TGM2-mediated mitochondria-associated endoplasmic reticulum membranes2026
  4. 4Association of Periodontal Pathogens and Their Inflammatory Mediators With Alzheimer’s Disease Neurodegeneration: A Systematic Review2026
  5. 5Vascular burden attenuates the TDP-43-TMEM106B pathological relationship in neurodegenerative disease with and without Alzheimer disease neuropathological change2026