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April 26, 2026BMC MicrobiologyOpen Access

High prevalence of blaNDM gene among a series of carbapenem-resistant Enterobacterales isolates from children less than one year old in Niger

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Authors

IMIssoufou Noma MassirYAYacouba AbdourahamaneTOTapha Ounoussa

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Overview

Prospective case series reveals high blaNDM prevalence in carbapenem-resistant Enterobacterales, indicating critical resistance challenges in infants.

Key Points

  • To evaluate the molecular epidemiology and antimicrobial susceptibility of carbapenem-resistant Enterobacterales in infants under one year in Niger.
  • Analyzed 14 isolates from children under one year old.
  • Identified bacterial species and detected carbapenemase genes.
  • Assessed antimicrobial susceptibility to various antibiotics.
  • 50.0% of isolates contained the blaNDM gene.
  • High resistance rates to fluoroquinolones and aminoglycosides were observed.
  • Cefiderocol showed preserved activity across carbapenemase genotypes.

Cite This Study

Massir et al. (2026) studied this question.

synapsesocial.com/papers/69edab424a46254e215b355ehttps://doi.org/10.1186/s12866-026-05094-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NDM‑mediated cefiderocol resistance among a series of carbapenem‑resistant Gram‑negative bacilli isolates in Niger2026
  2. 2Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger2025 · 2 citations
  3. 3Emergence of carbapenem-producing enterobacteriaceae (CPE) and other multidrug-resistant gram-negative bacteria in neonates at a tertiary-level NICU in Tanzania: a point prevalence study2025 · 3 citations
  4. 4Whole-genome sequencing analysis of clinical carbapenemase-producing bacteria isolated in Dakar, Senegal2026
  5. 5Molecular epidemiology and clinical profiles of carbapenem-resistant Enterobacterales in neonates from two large children’s hospitals in southwestern China2026